北京索萊寶科技
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產品型號：K106557P
更新時間：2022-08-15
廠商性質：生產廠家
訪 問 量 ：957
010-50973130
產品分類
Anti-AKT1+2+3 Polyclonal Antibody
| 英文名稱 | Anti-AKT1+2+3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA |
| 應用 | WB |
| 稀釋比例 | WB 1:3000. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 65kDa |
| Gene ID | 207 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human AKT1+2+3 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human AKT1+2+3 |
| Subcellular Locations | Cell membrane Cytoplasm Nucleus |
| Swiss Prot | P31749 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
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