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產(chǎn)品中心抗體Polyclonal AntibodyK106458PAnti-MYC Polyclonal Antibody
產(chǎn)品型號：K106458P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1142
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產(chǎn)品分類
Anti-MYC Polyclonal Antibody
| 英文名稱 | Anti-MYC Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | BHLHE39;c-Myc;MRTL;MYCC |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 63kDa |
| Gene ID | 4609 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human MYC |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human MYC |
| Swiss Prot | P01106 |
| Subcellular Locations | Nucleus Cytoplasm |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
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